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WG 5: Modulation of MRCs for therapeutic purposes

Main objective: development of new options for the manipulation and therapeutic application of MRCs. 

Methods and means:

This WG aims at translating achievements from WG 1-3 to preclinical models and ultimately into clinical studies with the help of WG 4.

Based on results from WG 1-4 this WG will:

  • Define monitoring parameters and endpoints suitable for qualitative and quantitative measures of MRC modulation in vivo.
  • Discuss and define the suitability, applicability and the translational value of models analysed in WG 4.
  • Discuss and suggest early clinical trial protocols for therapeutic modulation of MRC function in patients.
  • Seek advice from and closely communicate with regulatory authorities.