Mye-EUNITER
 

Carmody, Ruaidhri

Research interests focus on the molecular analysis of macrophage and their function in chronic inflammatory disease. My laboratory focuses the transcriptional regulation of inflammation with a particular emphasis on the transcription factor family NF-κB. The primary goal of the laboratory is to understand the molecular mechanisms by which gene transcription is regulated during inflammation and to develop ways to exploit transcriptional regulators for therapeutic benefit.

Models available:

Macrophage immunobiology, toll-like receptors, innate tolerance, analysis of transcription factor function, transcriptomics, pre-clinical mouse models of rheumatoid arthritis.

Cells available:

Macrophages, monocytes, B cells.

Technology available:

Molecular biology, transcriptomics, bioinformatics, animal models of inflammation including rheumatoid arthritis.

Key publications related to Mye-EUNITER:

  1. Identification of a unique hybrid macrophage-polarization state following recovery from lipopolysaccharide tolerance. O'Carroll C, Fagan A, Shanahan F, Carmody RJ. J Immunol. 2014 Jan 1;192(1):427-36.
  2. Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription. Colleran A, Collins PE, O'Carroll C, Ahmed A, Mao X, McManus B, Kiely PA, Burstein E, Carmody RJ. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):618-23.
  3. Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Yan Q, Carmody RJ, Qu Z, Ruan Q, Jager J, Mullican SE, Lazar MA, Chen YH. Proc Natl Acad Sci U S A. 2012 Aug 13. PMID: 22891325.
  4. Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis. Kreisel D, Sugimoto S, Tietjens J, Zhu J, Yamamoto S, Krupnick AS, Carmody RJ, Gelman AE. J Clin Invest. 2011;121(1):265-76.

Contact details:

Institute of Infection, Immunity and Inflammation
Sir Graham Davies Research Building
Room 316
G12 8TA Glasgow
United Kingdom
Tel. +441413305945
Ruaidhri.Carmody@glasgow.ac.uk