Mye-EUNITER
 

Cassetta, Luca

Luca's main scientific interest is primarily focused on the genomic wide and flow cytometric characterisation of human monocytes and macrophages in cancer.

Models available:

  • HIV-1
  • Breast cancer
  • Tumor Microenvironment
  • Human and Mouse 

Cells available:

  • Macrophages
  • Human and Mouse Monocytes

Technology available:

  • Flow Cytometry

Key publications related to Mye-EUNITER:

  1. Yeo EJ*, Cassetta L*, Qian BZ*, Lewkowich I, Li JF, Stefater JA 3rd, Smith AN, Wiechmann LS, Wang Y, Pollard JW, Lang RA. Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer. Cancer Res. 2014 Jun 1; 74(11):2962-73.

  2. Cassetta L, Kajaste-Rudnitski A, Coradin T, Saba E, Chiara GD, Barbagallo M, Graziano F, Alfano M, Cassol E, Vicenzi E, Poli G. M1 polarization of human monocyte-derived macrophages restricts pre-and post-integration steps of HIV-1 replication. AIDS. 2013 Jul 31; 27(12):1847-56.

  3. Cassetta L, Fortunato O, Adduce L, Rizzi C, Hering J, Rovere-Querini P, Bianchi ME, Alfano M, Poli G. Extracellular high mobility group box-1 inhibits R5 and X4 HIV-1 strains replication in mononuclear phagocytes without induction of chemokines and cytokines. AIDS, 2009; 23(5):567-77.

  4. Cassol E, Cassetta L, Rizzi C, Gabuzda D, Alfano M, Poli G. Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin mediates HIV-1 Infection of and Transmission by M2a-Polarized Macrophages In Vitro. AIDS. 2013 Mar 13;27(5):707-16.

  5. Cassol E1, Cassetta L, Rizzi C, Alfano M, Poli G. M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms. J Immunol. 2009 May 15;182(10):6237-46. doi: 10.4049/jimmunol.0803447.

Contact details:

University Of Edinburgh
Centre for Reproductive Health
47 Little France Crescent
EH16 4TJ Edinburgh
United Kingdom
Tel. +447754413420
v1lcasse@staffmail.ed.ac.uk 

Researcher Spotlight:

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Luca Cassetta graduated in Biotechnology (2003), conducted his Master studies in Industrial Biotechnology (2004-2005) and carried out his PhD in the field of HIV immunology at the University of Milan (2007-2010), studying the role of macrophage polarisation in HIV infection.

He then moved to the Albert Einstein Medical College (NY, USA) for postdoctoral training (2011-2013) where he worked in the field of tumor immunology with a special focus on human tumour associated macrophages in breast cancer.

He is currently working at the University of Edinburgh as a senior postdoc in the lab of Jeffrey Pollard.

His main scientific interest is primarily focused on the genomic wide and flow cytometric characterisation of human monocytes and macrophages in cancer.

Luca is Working Group 1 leader together with Gosse Adema, and he is the UK co-representative together with Jeffrey Pollard in the COST Network Mye-EUNITER.