Čokić, Vladan P.

Research interests focus on the

Models available:

Myeloproliferative neoplasms, inflammation factors and regulation, angiogenesis, erythroid cells, thrombosis.

The cancer-associated inflammation factors are dysregulated in cancers. Present therapeutic protocols do not address cancer-associated inflammation, essentially because of incomplete understanding of its molecular mechanism. Myeloproliferative neoplasms (MPNs), a group of hematologic malignancies that includes essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), have been described as a human inflammation model for cancer development. 

Cells available:

Myeloproliferative neoplasms: Hematopoietic progenitors, granulocytes, erythrocytes, mononuclear cells, bone marrow tissue, JAK2V617F mutation positive cells line. 

Technology available:

  • Flow cytometry
  • Real time PCR
  • Immunohistochemistry
  • cDNA microarrays
  • Western blot
  • Cell cultures
  • Mouse models

Key publications related to Mye-EUNITER:

  1. Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN. JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. J Transl Med. 2012;10:116.

  2. Cokic VP, Smith RD, Biancotto A, Noguchi CT, Puri RK, Schechter AN. Globin gene expression in correlation with G protein-related genes during erythroid differentiation. BMC Genomics. 2013;14:116.

  3. Cokic VP, Santibanez JF. JAK2 and TGF-beta signal transduction targeted therapies in MPNs. Bentham Science: Frontiers in Anti-Cancer Drug Discovery 2014;3(2):32-108. ISBN: 978-1-60805-885-3

  4. Beleslin-Cokic BB, Cokic VP, Suresh S, Wirt S, Noguchi CT. Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells. Microvasc Res. 2014;92:34-40.

  5. Vignjević S, Budeč M, Marković D, Dikić D, Mitrović O, Mojsilović S, Durić SV, Koko V, Cokić BB, Cokić V, Jovčić G. Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis. J Cell Mol Med. 2014;18:91-103.