Ersvær, Elisabeth

My research focus spans from T cell immunology towards clinical relevance of monocyte-lineage characterization in patients with leukemia.

Models available:

Human primary peripheral blood cells
Leukemia and PB stem cell grafts

Cells available:

Myeloid monocyte-lineages (humans)

Technology available:

Flow cytometry (FACS Verse. Will have the opportunity to use a CyTOF)
Seahorse XFe96
In vitro cell culture

Key publications related to Mye-EUNITER:

  1. Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø. n vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22. J Interferon Cytokine Res. 2008 May;28(5):297-310. doi: 10.1089/jir.2007.0052. PMID: 18547160
  2. Ersvaer E, Brenner AK, Vetås K, Reikvam H, Bruserud Ø. Effects of cytarabine on activation of human T cells - cytarabine has concentration-dependent effects that are modulated both by valproic acid and all-trans retinoic acid. BMC Pharmacol Toxicol. 2015 May 2;16:12. doi: 10.1186/s40360-015-0012-2. PMID: 25934555
  3. Bredholt T*, Ersvær E*, Erikstein BS, Sulen A, Reikvam H, Aarstad HJ, Johannessen AC, Vintermyr OK, Bruserud Ø, Gjertsen BT. Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. BMC Pharmacol Toxicol. 2013 Jul 11;14:35. doi: 10.1186/2050-6511-14-35. *Equal authors
  4. Ersvaer E, Liseth K, Skavland J, Gjertsen BT, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010 Jul 9;11:38. doi: 10.1186/1471-2172-11-38. PMID: 20618967
  5. Liseth K, Ersvær E, Abrahamsen JF, Nesthus I, Ryningen A, Bruserud Ø. Long-term cryopreservation of autologous stem cell grafts: a clinical and experimental study of hematopoietic and immunocompetent cells.Transfusion. 2009 Aug;49(8):1709-19. doi: 10.1111/j.1537-2995.2009.02180