Fridlender, Zvi G.

Models available:

  • Tumor associated neutrophils and cancer related circulating neutrophils
  • Granulocytic MDSC
  • Macrophages polarization
  • Cancer immunotherapy
  • Internal medicine and pulmonology

Technology available:

  • Murine models of thoracic malignancies (lung cancer, mesothelioma, breast cancer)

Key publications related to Mye-EUNITER:

  1. Mishalian I, Bayuh R, Levy L, Zolotarov L, Michaeli J, Fridlender ZG. Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression. Cancer Immunol Immunother. 2013 Nov;62(11):1745-56.

  2. Fridlender ZG, Jassar A, Mishalian I, Wang LC, Kapoor V, Cheng G, Sun J, Singhal S, Levy L, Albelda SM. Using macrophage activation to augment immunotherapy of established tumours. Br J Cancer. 2013 Apr 2;108(6):1288-97.

  3. Fridlender ZG, Albelda SM Tumor-associated neutrophils: friend or foe? Carcinogenesis. 2012 May;33(5):949-55.

  4. Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM. Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS One. 2012;7(2):e31524.

  5. Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, Worthen GS, Albelda SM. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell. 2009 Sep 8;16(3):183-94.