Mye-EUNITER
 

Hartl, Dominik

Models available:

Human/Patient cohorts:

  • Lung diseases (Cystic fibrosis)
  • GvHD
  • Fungal infections

Mouse:

  • Lung diseases (Cystic fibrosis)
  • Fungal & Bacterial infection models

Cells available:

MDSCs

  • Induction and function of neutrophilic MDSCs
  • Survival of MDSCs
  • Interaction with other immune cells
  • In vivo imaging/trafficking
  • Depletion and adoptive transfer in vivo

Tregs

  • Interaction with other immune cells
  • In vivo imaging/trafficking
  • Depletion and adoptive transfer in vivo

Technology available:

  • FACS
  • MACS
  • Mouse models
  • ELISA
  • siRNA
  • qPCR
  • Immunoblotting (incl. Subcellular fractionation a la Borregaard)
  • Confocal
  • Phagocytosis, ROS, killing
  • Migration in vitro and in vivo
  • Adoptive cell transfer in murine models

Key publications related to Mye-EUNITER:

  1. Rieber N, Brand A, Hector A, Graepler-Mainka U, Ost M, Schäfer I, Wecker I, Wirth A, Mays L, Zundel S, Fuchs J, Handgretinger R, Stern M, Hogardt M, Döring G, Riethmüller J, Kormann M and Hartl D. Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease. The Journal of Immunology. 2013; Feb 1

  2. Hartl D, Latzin P, Hordijk P, Marcos V, Rudolph C, Woischnik M, Krauss-Etschmann S,  Koller B, Reinhardt D, Roscher A., Roos D and Griese M. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nature Medicine 2007, Dec;13(12):1423-30, Selected for Faculty of 1000 Biology

  3. Rieber N, Wecker I, Neri D, Fuchs K, Schäfer I, Brand A, Lang P, Bethge W, Amon O, Handgretinger R, Hartl D. Extracorporeal photopheresis increases neutrophilic myeloid-derived suppressor cells in patients with graft-versus host-disease. Bone Marrow Transplantation 2014 Jan 27, IF: 3.5

  4. Rieber N, Gille C, Köstlin N, Schäfer I, Spring B, Ost M, Spieles H, Kugel HA, Pfeiffer M, Heininger V, Alkhaled M, Hector A, Mays L, Kormann M, Zundel S, Fuchs J, Handgretinger R, Poets CF and Hartl D. Neutrophilic myeloid-derived suppressor cells in cord blood modulate innate and adaptive immune responses. Clin Exp Immunol. 2013; May 24, IF: 3.3

Contact details:

Pediatric Infectious Diseases, Immunology & Pneumology/Cystic fibrosis
Universitätsklinik für Kinder-und Jugendmedizin (Abteilung I)
Hoppe-Seyler-Strasse 1
72076 Tübingen
Germany
Phone: +49-7071-29-81460
Fax: +49-7071-29-4449
Dominik.Hartl@med.uni-tuebingen.de