Ler, Daria

Research that I have done so far and my ongoing projects, referred to studies related to the field of molecular oncology and pathology as well as immunogenetics, and are closely associated with potential clinical trials in order to improve the diagnosis/prognosis of the disease and its targeted therapy. Research projects were and are directed to exploring and finding new potential biomarkers in cancers on molecular level.

Models available:

Breast cancer
Colorectal cancer

Cells available:

  • MCF7
  • MDA MB 324
  • HeLa

Technology available:

  • Molecular diagnostics: Real Time PCR- RotorGene Eppendorf and basic equipment for molecular genetic prepartion of samples ie PCR mastercycler, centrifuges, laminar flow, thermomixer etc.
  • Pathohistology: immunochemistry assays, pathological microskops, microtom.
  • Biochemistry: Advia CentaurCP Immunoassay system - Siemens, BA400 Biosystems for biochemistry, ABXMicrosES60 CBC.

Key publications related to Mye-EUNITER:

  1. D.Stefatic, M. Riederer, M.Balic, S.Stanzer, B.Janesch, M.Resel, D.Ler, H. Samonigg, T. Bauernhofer. Optimization of diagnostic ELISA-based tests for the detection of auto-antibodies against tumor antigens in human serum, Bosn J Basic Med Sci 2008 Aug; 8(3): 245-50.

  2. L.Kapur, N. Pojskic, J.Ramic, J. Krehic, N.Pojskic, D.Stefatic. Is psychosis correlated with differential HSP90 expression? European Journal of Human Genetics 16/2 (2008):344.

  3. Ler D., Milde-Langosch K., Kapur-Pojskic L., Bajrovic K. Extracellular catalytic subunit expression of cAMP-dependent protein kinase A in human mammary carcinoma cells. Period biol (2012) 114/1:76.

  4. D. Ler, M. Riederer. Establishment of diagnostic test for the detection of tumor markers. ISBN: 978-3-639-23879-2.

  5. N.Kelesoglu, D. Ler, D. Efremov, M.Suljagic. Loss of PHLPP1 tumor supressor enhances Bcr-induced pro-survival signaling in chronic lymphocytic leukemia. Period Biol (2012) 114/1:15