Mócsai, Attila

Research interests focus on molecular mechanisms of phagocyte function, neutrophils, autoimmune inflammation.

Models available:

  • K/BxN serum-transfer arthritis
  • autoantibody-induced skin blistering
  • TNF transgene-induced arthritis

Cells available:

1) Transgenic mouse models with:

  • Targeted deletion of various cell surface receptors (integrins,
  • Fc-receptors) and intracellular signaling molecules (tyrosine kinase pathway components) -floxed mutations in various intracellular signal transduction molecules allowing lineage-specific deletion -various lineage-specific Cre-expressing mouse strains -mutants allowing deletion of certain myeloid lineages -disease models of autoimmune and inflammatory diseases in mice

2) Access to rheumatology patients and smaller cohorts

Technology available:

Complete and lineage-specific gene deletion bone marrow transplantation in vivo imaging

Key publications related to Mye-EUNITER:

  1. Weber FC, Németh T, Csepregi JZ, Dudeck A, Roers A, Ozsvári B, Oswald E, Puskás LG, Jakob T, Mócsai A* and Martin SF*: Neutrophils are required for both the sensitization and elicitation phases of contact hypersensitivity. J Exp Med 2015, 212: 15-22.

  2. Futosi K, Németh T, Pick R, Vántus T, Walzog B and Mócsai A: Dasatinib inhibits pro-inflammatory functions of mature human neutrophils. Blood 2012, 119: 4981-4991. IF: 9,060

  3. Jakus Z, Simon E, Balázs B and Mócsai A: Genetic deficiency of Syk protects mice from autoantibody-induced arthritis. Arthritis Rheum 2010, 62: 1899-1910.IF: 8,435.

  4. Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA and Mócsai A: The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med 2014, 211:1993-2011.

  5. Mócsai A: Diverse novel functions of neutrophils in immunity, inflammation and beyond. J Exp Med 2013, 210: 1283-1299.