Mye-EUNITER
 

Müller-Trutwin, Michaela

Models available:

  • HIV/AIDS, Human cohorts of HIV-infected patients (ANRS); non-human primate models, Macacca cynomolgus (persistent infection by SIV associated with chronic inflammation);
  • Chlorocebus sabaeus (spontaneous resolution of inflammation after SIV infection and protection against disease)

Cells available:

  • Plasmacytoid dendritic cells
  • Myeloid dendritic cells
  • Monocytes
  • Macrophages

Technology available:

  • Methods in Immunology, epigenetics, metabolism (from single cell to whole genome)

Key publications related to Mye-EUNITER:

  1. Paiardini M and MC. Müller-Trutwin. Immune activation in HIV infection. Immunol Rev. 2013 Jul;254(1):78-101.

  2. B. Jacquelin, G. Petitjean, D. Kunkel, A-S. Liovat, S.P. Jochems, K.A. Rogers, M.J. Ploquin, F. Barré-Sinoussi, N. Dereuddre-Bosquet, P. Lebon, R. Le Grand, F. Villinger & M. Müller-Trutwin. Innate Immune Responses and Rapid Control of Inflammation in African Green Monkeys Treated or not with Interferon-Alpha during Primary SIVagm Infection. PLoS Pathog. 2014 Jul 3;10(7):e10042412014

  3. Liovat AS, MA Rey-Cuillé, C Lecuroux, B Jacquelin, I Girault, G Petitjean, Y Zitoun, A Venet, F Barré-Sinoussi, P Lebon, L Meyer, M Sinet & MC. Müller-Trutwin. Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. PLoS One. 2012;7(10):e46143. doi: 10.1371

Contact details:

Institut Pasteur
HIV, inflammation and Persistence Unit
Department of Virology
75015 Paris
France
Tel. +33140613969
mmuller@pasteur.fr

Researcher Spotlight:

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Michaela Müller-Trutwin studied Biology at the University in Bonn and Frankfurt, Germany. She obtained her PhD from Paris University, France in the Barré-Sinoussi lab. She worked at Research Institutes in West- and Central Africa, in particular at the Institut Pasteur in Bangui and at the CIRMF in Gabon and collaborated with the Institut Pasteur in South-East Asia. In 2009, she obtained the position of Associate Professor at Institut Pasteur. In 2014 she was appointed head of the Unit “HIV, inflammation and persistence”. As Dean, she directed the Pasteur-Paris University International PhD Program from its beginning in 2008 until 2013. Among other duties, she serves as a Steering Committee member of the Center for Innovative Therapies for infectious Disease models (IDMIT). Her research has contributed to the discovery of several HIV and SIV viruses, such as the 1st SIV from African green monkeys in Central Africa and the first SIV from chimpanzees in Cameroon as well as to the demonstration of the expansion of HIV-1 subtype A in Central African Republic at the expense of other HIV-1 subtypes. Her work was instrumental for the development of tools allowing the study of African monkeys as models for the protection against AIDS. Her work delivered the first indirect indication that natural hosts of SIV are protected against AIDS without controlling viral replication. Her team discovered that the lack of AIDS in the natural hosts of SIV is associated with a rapid control of inflammation. Today, the lab is focused on deciphering the early host immune responses to identify factors involved in the protection against chronic inflammation and control of viral reservoirs in SIV and HIV-1 infections with the aim to translate the findings into clinical HIV research. Her work has been honored for instance by the French Medical Research Award and the Pasteur Vallery Radot award.

Within Mye-EUNITER, Michaela Müller-Trutwin is a Working Group 4 leader together with Karin Loré, and is the French representative in the consortium together with Maria Cristina Cuturi.