Papadaki, Helen A.

Research interests focus on the mechanisms responsible for the generation of the inflammatory bone marrow (BM) microenvironment in patients with Myelodysplastic syndromes (MDS), which is a group of haematopoietic stem cell disorders characterized by ineffective hematopoiesis and a high risk of transformation to acute myeloid leukemia. Typically in MDS patients, an inflammatory BM milieu consisting of pro-inflammatory cytokines and pro-apoptotic mediators seems to induce the apoptotic death of the normal BM progenitor/precursor cells and also allows the growth and expansion of the MDS clone.

Macrophages are part of the normal hematopoietic BM niche and, also, constitute a central member of the inflammatory cells in the MDS BM stroma.

Our research goal is to examine the possible involvement of BM macrophages in MDS development by studying their quantitative and functional characteristics in MDS patients and by examining the possible involvement of the BM macrophages in the development of ineffective haematopoiesis in MDS and their possible relationship with the progression of the disease and its transformation to acute myeloid leukemia.

Technology available:

  • Our patient samples belong to the group of MDS and also Chronic Idiopathic Neutropenia CIN which is the benign form of BM failure syndromes such as MDS.
  • We can isolate and culture BM haemopoietic and non haemopoietic cells (mesenchymal stem cells), and also develop co-culture systems that are a model of the BM microenvironment.