Verginis, Panos

Models available:

  • Mouse models of autoimmune diseases (EAE, CIA and SLE)
  • Tumor mouse models (B16 melanoma)
  • MS and RA patient cohorts
  • Melanoma patient cohorts

Cells available:

  • Myeloid-derived suppressor cells
  • Regulatory T cells

Technology available:

  • in vivo and in vitro cellular immunology assays (adoptive transfers, cell suppressions)
  • flow cytometry and cell-sorting, 8 colors immunophenotyping
  • DNA microarrays analysis

Key publications related to Mye-EUNITER:

  1. Ioannou M., Alissafi T., Boon L., Boumpas D. and Verginis P.  In vivo ablation of plasmacytoid dendritic cells inhibits autoimmunity through expansion of myeloid-derived suppressor cells. The Journal of Immunology, 2013. 190: 2631-2640.

  2. Ioannou M., Alissafi T., Lazaridis I., Deraos G., Matsoukas J., Gravanis A., MastorodemosV.,

  3. Plaitakis A., Sharpe A., Boumpas D. and Verginis P. Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. The Journal of Immunology, 2012. 188: 1136-1146.

  4. Kavousanaki M, Makrigiannakis A, Boumpas D, Verginis P.  Novel role of plasmacytoid dendritic cells (pDCs) in humans: pDCs induce Tr1 regulatory T cells in rheumatoid arthritis patients responding to therapy. Arthritis and Rheumatism 2010, 62(1): 53-63.

  5. Verginis P., McLaughlin KA., Wucherpfennig KW., Von Boehmer H., Apostolou I. Induction and visualization of antigen-specific regulatory T cells in wild-type mice: implications for transplantation tolerance. Proc. Natl. Acad. Sci. USA, 2008 105 (9), 3479-3484.

  6. Verginis P., Li S.H., Carayanniotis G. Tolerogenic semi-mature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cells.  The Journal of Immunology, 2005, Jun 1; 174(11): 7433-7439.