Mye-EUNITER Publications



Brandau S. MDSC and beyond: a symposium-in-writing on myeloid cells with immunoregulatory activity by members of the Mye-EUNITER network(Editorial). Cancer Immunol Immunother. 2019 Mar 18. doi: 10.1007/s00262-019-02325-9

Bizymi N, Bjelica S, Kittang AO, Mojsilovic S, Velegraki M, Pontikoglou C, Roussel M, Ersvær E, Santibañez JF, Lipoldová M, Papadaki H. Myeloid-Derived Suppressor Cells in Hematologic Diseases. Promising Biomarkers and Treatment Targets. HemaSphere, 2019;3:1. doi: 10.1097/HS9.0000000000000168

Cassetta L, Baekkevold ES, Brandau S, Bujko A, Cassatella MA, Dorhoi A, Krieg C, Lin A, Loré K, Marini O, Pollard JW, Roussel M, Scapini P, Umansky V, Adema GJ. Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates. Cancer Immunol Immunother. 2019 Jan 25. doi: 10.1007/s00262-019-02302-2

Dorhoi A, Glaría E, Garcia-Tellez T, Nieuwenhuizen NE, Zelinskyy G, Favier B, Singh A, Ehrchen J, Gujer C, Münz C, Saraiva M, Sohrabi Y, Sousa AE, Delputte P, Müller-Trutwin M, Valledor AF. MDSCs in infectious diseases: regulation, roles, and readjustment. Cancer Immunol Immunother. 2018 Dec 19. doi: 10.1007/s00262-018-2277-y

Amodio G, Cichy J, Conde P, Matteoli G, Moreau A, Ochando J, Oral BH, Pekarova M, Ryan EJ, Roth J, Sohrabi Y, Cuturi MC, Gregori S. Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation. Cancer Immunol Immunother. 2018 Oct 24. doi: 10.1007/s00262-018-2264-3

Umansky V, Adema GJ, Baran 4, Brandau S, Van Ginderachter JA, Hu X, Jablonska J, Mojsilovic S, Papadaki HA, Pico de Coaña Y, Santegoets KCM, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG. Interactions among myeloid regulatory cells in cancer. Cancer Immunol Immunother. 2018 Jul 12. doi: 10.1007/s00262-018-2200-6

Bruger AM, Dorhoi A, Esendagli G, Barczyk-Kahlert K, van der Bruggen P, Lipoldova M, Perecko T, Santibanez J, Saraiva M, Van Ginderachter JA, Brandau S. How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions. Cancer Immunol Immunother. 2018 May 21. doi: 10.1007/s00262-018-2170-8

Other Publications

Bruger AM, Vanhaver C, Bruderek K, Amodio G, Tavukçuoğlu E, Esendagli G, Gregori S, Brandau S, van der Bruggen P. Protocol to assess the suppression of T-cell proliferation by human MDSC. Methods in Enzymology, 2019. doi: 10.1016/bs.mie.2019.05.046

Silvestre-Roig C, Fridlender ZG, Glogauer M, Scapini P. Neutrophil Diversity in Health and Disease. Trends Immunol. 2019 May 31. pii: S1471-4906(19)30101-2. doi: 10.1016/ [Epub ahead of print] Review.

Lopez-Yrigoyen M, Yang CT, Fidanza A, Cassetta L, Taylor AH, McCahill A, Sellink E, von Lindern M, van den Akker E, Mountford JC, Pollard JW, Forrester LM. Genetic programming of macrophages generates an in vitro model for the human erythroid island niche. Nat Commun. 2019 Feb 20;10(1):881. doi: 10.1038/s41467-019-08705-0

Costa S, Bevilacqua D, Cassatella MA, Scapini P. Recent advances on the crosstalk between neutrophils and B or T lymphocytes. Immunology. 2018 Sep 27. doi: 10.1111/imm.13005

Mačák Kubašková T, Mudroňová D, Velebný S, Hrčková G. The utilisation of human dialyzable leukocyte extract (IMMODIN) as adjuvant in albendazole therapy on mouse model of larval cestode infection: Immunomodulatory and hepatoprotective effects. Int Immunopharmacol. 2018 Oct 10;65:148-158. doi: 10.1016/j.intimp.2018.09.045

Stoll H, Ost M, Singh A, Mehling R, Neri D, Schäfer I, Velic A, Macek B, Kretschmer D, Weidenmaier C, Hector A, Handgretinger R, Götz F, Peschel A, Hartl D, Rieber N. Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells. Front Cell Infect Microbiol. 2018 Sep 13;8:321. doi: 10.3389/fcimb.2018.00321

Pylaeva E, Harati MD, Spyra I, Bordbari S, Strachan S, Thakur BK, Höing B, Franklin C, Skokowa J, Welte K, Schadendorf D, Bankfalvi A, Brandau S, Lang S, Jablonska J. NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils. Int J Cancer. 2018 Aug 19. doi: 10.1002/ijc.31808. [Epub ahead of print]

Rundgren IM, Bruserud Ø, Ryningen A, Ersvær E. Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood. J Immunol Methods. 2018 Jun 12. pii: S0022-1759(17)30510-0. doi: 10.1016/j.jim.2018.06.003. [Epub ahead of print]

Alissafi T, Hatzioannou A, Mintzas K, Barouni RM, Banos A, Sormendi S, Polyzos A, Xilouri M, Wielockx B, Gogas H, Verginis P. Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells. J Clin Invest. 2018 Jun 19. pii: 120888. doi: 10.1172/JCI120888

Lang S, Bruderek K, Kaspar C, Höing B, Kanaan O, Dominas N, Hussain T, Droege F, Eyth CP, Hadaschik B, Brandau S. Clinical relevance and suppressive capacity of human MDSC subsetsClin Cancer Res. 2018 Jun 18. pii: clincanres.3726.2017. doi: 10.1158/1078-0432.CCR-17-3726.

Butcher SK, O'Carroll CE, Wells CA, Carmody RJ. Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages. Front. Immunol., 14 May 2018. doi: 10.3389/fimmu.2018.00933

Mensurado S, Rei M, Lança T, Ioannou M, Gonçalves-Sousa N, Kubo H, Malissen M, Papayannopoulos V, Serre K, Silva-Santos B. Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress. PLoS Biol. 2018 May 11;16(5):e2004990. doi: 10.1371/journal.pbio.2004990.

Lopez-Yrigoyen M, Fidanza A, Cassetta L, Axton RA, Taylor AH, Meseguer-Ripolles J, Tsakiridis A, Wilson V, Hay DC, Pollard JW, Forrester LM. A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and in vivo tracking of therapeutic cells. Phil. Trans. R. Soc. B.  373: 20170219.

Sohrabi Y, Lipoldová M. Mannose Receptor and the Mystery of Nonhealing Leishmania major Infection. Trends Parasitol. 34 (5): 355-356, 2018 doi: 10.1016/

Bartneck, M. Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines. Chapter in R. Bawa, J. Szebeni, T. Webster and G. F. Audette. (Editors): Immune Aspects of Biopharmaceuticals and Nanomedicines, Pan Stanford Publishing, Singapore (2018) [ISBN 978-981-4774-52-9 (Hardbound), 978-0-203-73153-6 (eBook)].

Sohrabi Y, Godfrey R, Findeisen HM. Altered Cellular Metabolism Drives Trained Immunity. Trends Endocrinol Metab. 2018 Apr 4. pii: S1043-2760(18)30057-2. doi: 10.1016/j.tem.2018.03.012. [Epub ahead of print]

Cassetta L, Kitamura T. Targeting Tumor-Associated Macrophages as a Potential Strategy to Enhance the Response to Immune Checkpoint Inhibitors. Front. Cell Dev. Biol., 04 April 2018. doi: org/10.3389/fcell.2018.00038

Cardoso A, Castro AG, Martins AC, Carriche GM, Murigneux V, Castro I, Cumano A, Vieira P, Saraiva M. The Dynamics of interleukin-10-afforded Protection during Dextran sulfate sodium-induced colitis. Front. Immunol., 01 March 2018. doi: 10.3389/fimmu.2018.00400

Esendagli G, Yoyen-Ermis D, Guseinov E, Aras C, Aydin C, Uner A, Hamaloglu E, Karakoc D. Impact of repeated abdominal surgery on wound healing and myeloid cell dynamics. J Surg Res. 2018 Mar;223:188-197. doi: 10.1016/j.jss.2017.11.030. Epub 2017 Dec 1.

Yoyen-Ermis D, Ozturk-Atar K, Kursunel MA, Aydin C, Ozkazanc D, Gurbuz UM, Uner A, Tulu M, Calis S, Esendagli G. Tumor-induced myeloid cells are reduced by gemcitabine-loaded PAMAM dendrimers decorated with anti-Flt1 antibody. Mol Pharm. 2018 Feb 26. doi: 10.1021/acs.molpharmaceut.7b01075. [Epub ahead of print]

den Brok MH, Raaijmakers TK, Collado-Camps E, Adema GJ. Lipid Droplets as Immune Modulators in Myeloid Cells. Trends Immunol. 2018 Feb 22. pii: S1471-4906(18)30023-1. doi: 10.1016/ [Epub ahead of print] Review.

Gregori S, Roncarolo MG. Engineered T Regulatory Type 1 Cells for Clinical Application. Front Immunol. 2018 Feb 15;9:233. doi: 10.3389/fimmu.2018.00233.

Agod Z, Pazmandi K, Bencze D, Vereb G, Biro T, Szabo A, Rajnavolgyi E, Bacsi A, Engel P, Lanyi A. Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8. Front Immunol. 2018 Jan 26;9:62. doi: 10.3389/fimmu.2018.00062. eCollection 2018.

Masemann D, Köther K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S. Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages. OncoImmunology. 2018, VOL. 0, NO. 0, e1423171. doi: 10.1080/2162402X.2017.1423171

Kitamura T, Doughty-Shenton D, Cassetta L, Fragkogianni S, Brownlie D, Kato Y, Carragher N, Pollard JW. Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer. Front. Immunol., 2018 Jan 17.

Krieg C, Nowicka M, Guglietta S, Schindler S, Hartmann FJ, Weber LM, Dummer R, Robinson MD, Levesque MP, Becher B. High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy. Nat Med. 2018 Jan 8. doi: 10.1038/nm.4466.

Dorhoi A., Du Plessis N. Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections. Front. Immunol., 2018 Jan 4.

Bujko A, Atlasy N, Landsverk OJB, Richter L, Yaqub S, Horneland R, Øyen O, Aandahl EM, Aabakken L, Stunnenberg HG, Bækkevold ES, Jahnsen FL. Transcriptional and functional profiling defines human small intestinal macrophage subsets. J Exp Med. 2017 Dec 22. pii: jem.20170057. doi: 10.1084/jem.20170057.

Lin A and Loré K. Granulocytes: new members of the antigen-presenting cell family. Front. Immunol., 2017 Dec 11.

Sevmis M, Yoyen-Ermis D, Aydin C, Bilgic E, Korkusuz P, Uner A, Hamaloglu E, Esendagli G, Karakoc D. Splenectomy-Induced Leukocytosis Promotes Intratumoral Accumulation of Myeloid-Derived Suppressor Cells, Angiogenesis and Metastasis. Immunol Invest. 2017 Oct;46(7):663-676. doi: 10.1080/08820139.2017.1360339.

OncoImmunology. Vol. 0 , Iss. 0,0 Article: e1356965, Published online: 16 Aug 2017. doi: 10.1080/2162402X.2017.1356965.

Drabczyk-Pluta M, Werner T, Hoffmann D, Leng Q, Chen L, Dittmer U, Zelinskyy G. Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection. Retrovirology. 2017 Aug 23;14(1):42. doi: 10.1186/s12977-017-0364-3.

Krstic J, Trivanovic D, Jaukovic A, Santibanez JF, Bugarski D. Metabolic plasticity of stem cells and macrophages in cancer. Front Immunol. 2017 Aug 09.

Masemann D, Boergeling Y, Ludwig S. Employing RNA viruses to fight cancer: novel insights into oncolytic virotherapy. Biol Chem. 2017 Jul 26;398(8):891-909. doi: 10.1515/hsz-2017-0103.

Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote LAPotter SA, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB. Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function. Blood Adv. 2017 Jun 13;1(14):947-960; doi:

Welsh P, Grassia G, Botha S, Sattar N, Maffia P. Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? Br J Pharmacol. 2017 Apr 13. doi: 10.1111/bph.13818. [Epub ahead of print] Review. PMID: 28409825

Shaul ME, Fridlender ZG. Neutrophils as active regulators of the immune system in the tumor microenvironment. J Leukoc Biol. 2017 Mar 6. pii: jlb.5MR1216-508R. doi: 10.1189/jlb.5MR1216-508R. [Epub ahead of print]

Verescakova H, Ambrozova G, Kubala L, Perecko T, Koudelka A, Vasicek O, Rudolph TK, Klinke A, Woodcock SR, Freeman BA, Pekarova M. Nitro-oleic acid critically regulates growth factor-induced differentiation of bone marrow-derived macrophages. Free Radic Biol Med. 2017 Mar;104:10-19. doi: 10.1016/j.freeradbiomed.2017.01.003. Epub 2017 Jan 4.

Reber LL, Gillis CM, Starkl P, Jönsson F, Sibilano R, Marichal T, Gaudenzio N, Bérard M, Rogalla S, Contag CH, Bruhns P and Galli SJ. Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide. J. Exp. Med. 2017 May 1;214(5):1249-1258. doi: 10.1084/jem.20161238. Epub 2017 Apr 6.

Vono M, Lin A, Norrby-Teglund A, Koup RA, Liang F, Loré K. Neutrophils acquire antigen presentation capacity to memory CD4+ T cells in vitro and ex vivo. Blood. 2017 Apr 6;129(14):1991-2001. doi: 10.1182/blood-2016-10-744441. Epub 2017 Jan 31.

Matalonga J, Glaria E, Bresque M, Escande C, Carbó JM, Kiefer K, Vicente R, León ME, Beceiro S, Pascual-García M, Serret J, Sanjurjo L, Morón-Ros S, Riera A, Paytubi S, Juarez A, Sotillo F, Lindbom L, Caelles C, Sarrias MR, Sancho J, Castrillo A, Chini EN, Valledor AF. The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism. Cell Reports. Volume 18, Issue 5, 31 January 2017, Pages 1241–1255. doi: 10.1016/j.celrep.2017.01.007

Marini O, Costa S, Bevilacqua D, Calzetti F, Tamassia N, Spina C, De Sabata D, Tinazzi E, Lunardi C, Scupoli MT, Cavallini C, Zoratti E, Tinazzi I, Marchetta A, Vassanelli A, Cantini M, Gandini G, Ruzzenente A, Guglielmi A, Missale F, Vermi W, Tecchio C, Cassatella MA, Scapini P. Mature CD10+ and immature CD10- neutrophils present in G-CSF-treated donors display opposite effects on T cells. Blood. 2017 Jan 4. pii: blood-2016-04-713206. doi: 10.1182/blood-2016-04-713206. [Epub ahead of print]

Amaral AJ, Andrade J, Foxall RB, Matoso P, Matos AM, Soares RS, Rocha C, Ramos CG, Tendeiro R, Serra-Caetano A, Guerra-Assunção JA, Santa-Marta M, Gonçalves J, Gama-Carvalho M, Sousa AE. miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replicationEMBO J. 2017 Feb 1;36(3):346-360. doi: 10.15252/embj.201694335. Epub 2016 Dec 19

Slapničková M, Volkova V, Čepičková M, Kobets T, Šíma M, Svobodová M, Demant P, Lipoldová M. Gene-specific sex effects on eosinophil infiltration in leishmaniasis. Biol Sex Differ. 2016 Nov 22;7:59. eCollection 2016.

Umansky V, Blattner C, Gebhardt C, Utikal J. The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression. Vaccines (Basel). 2016 Nov 3;4(4). pii: E36.

Umansky V, Blattner C, Fleming V, Hu X, Gebhardt C, Altevogt P, Utikal J. Myeloid-derived suppressor cells and tumor escape from immune surveillance. Semin Immunopathol. 2016 Oct 27. [Epub ahead of print].

Scapini P, Marini O, Tecchio C, Cassatella MA. Human neutrophils in the saga of cellular heterogeneity: insights and open questions. Immunol Rev. 2016 Sep;273(1):48-60. doi: 10.1111/imr.12448. Review.

Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, Mandruzzato S, Murray PJ, Ochoa A, Ostrand-Rosenberg S, Rodriguez PC, Sica A, Umansky V, Vonderheide RH, Gabrilovich DI. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 2016 Jul 6;7:12150. doi: 10.1038/ncomms12150.

Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, von Köckritz-Blickwede M, Schilling B, Brandau S, Weiss S, Jablonska J. Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer. 2016 Apr 15;138(8):1982-93. doi: 10.1002/ijc.29945.

Moses K, Brandau, S. Human neutrophils: Their role in cancer and relation to myeloid-derived suppressor cells. Semin Immunol. 2016 Apr;28(2):187-96. doi: 10.1016/j.smim.2016.03.018. Epub 2016 Apr 7.

Silva SL, Albuquerque AS, Serra-Caetano A, Foxall RB, Pires AR, Matoso P, Fernandes SM, Ferreira J, Cheynier R, Victorino RM, Caramalho I, Barata JT, Sousa AE. Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7. Oncotarget. 2016 Mar 15;7(11):12163-75. doi: 10.18632/oncotarget.7512.

Gielen PR, Schulte BM, Kers-Rebel ED, Verrijp K, Bossman SA, Ter Laan M, Wesseling P, Adema GJ. Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function. Neuro Oncol. 2016 Mar 22. pii: now034. [Epub ahead of print]

Andzinski L, Kasnitz N, Stahnke S, Wu CF, Gereke M, von Köckritz-Blickwede M, Schilling B, Brandau S, Weiss S, Jablonska J. Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human. Int J Cancer. 2016 Apr 15;138(8):1982-93. doi: 10.1002/ijc.29945. Epub 2015 Dec 17.

Baj-Krzyworzeka M, Mytar B, Szatanek R, Surmiak M, Węglarczyk K, Baran J, Siedlar M. Colorectal cancer-derived microvesicles modulate differentiation of human monocytes to macrophages. J Transl Med. 2016 Feb 2;14(1):36. doi: 10.1186/s12967-016-0789-9.

Moses K, Klein JC, Männ L, Klingberg A, Gunzer M, Brandau S. Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice. J Leukoc Biol. 2016 Jan 27. pii: jlb.1HI0715-289R. [Epub ahead of print]

Collins PE, Carmody RJ. The Regulation of Endotoxin Tolerance and its Impact on Macrophage Activation. Crit Rev Immunol. 2015;35(4):293-323.

Gielen PR, Schulte BM, Kers-Rebel ED, Verrijp K, Petersen-Baltussen HM, ter Laan M, Wesseling P, Adema GJ.  Increase in both CD14-positive and CD15-positive myeloid-derived suppressor cell subpopulations in the blood of patients with glioma but predominance of CD15-positive myeloid-derived suppressor cells in glioma tissue. J Neuropathol Exp Neurol. 2015 May;74(5):390-400. doi: 10.1097/NEN.0000000000000183.